Discovery of 'weak spot' in COVID-19 variants could lead to better treatment options
A discovery by a team of B.C. researchers may lead to improved COVID-19 treatment options that are effective against several variants of the disease.
Researchers at the University of British Columbia say they've found a "weak spot" in COVID-19 variants, including in the latest Omicron subvariants. Their findings were published in Nature Communications on Thursday.
"This is a highly adaptable virus that has evolved to evade most existing antibody treatments, as well as much of the immunity conferred by vaccines and natural infection," said Dr. Sriram Subramaniam, a professor at UBC's faculty of medicine and the study's senior author, in a news release.
"This study reveals a weak spot that is largely unchanged across variants and can be neutralized by an antibody fragment. It sets the stage for the design of pan-variant treatments that could potentially help a lot of vulnerable people."
The researchers, who worked with a team from the University of Pittsburgh, explained that while antibody treatments have been available for COVID-19, some are less effective against muted variants like Omicron.
"Antibodies attach to a virus in a very specific manner, like a key going into a lock. But when the virus mutates, the key no longer fits," Subramaniam explained.
"We've been looking for master keys — antibodies that continue to neutralize the virus even after extensive mutations."
Researchers believe they've identified a "master key" antibody fragment that's effective against COVID-19's Alpha, Beta, Gamma, Delta, Kappa, Epsilon and Omicron variants. It can attach itself to part of the virus' spike protein, blocking it from entering human cells.
By identifying a weak spot, researchers say drug makers can use the information to create new treatments that could even be effective against future variants.
"We now have a very clear picture of this vulnerable spot on the virus. We know every interaction the spike protein makes with the antibody at this site. We can work backwards from this, using intelligent design, to develop a slew of antibody treatments," Subramaniam said.
"Having broadly effective, variant-resistant treatments would be a game changer in the ongoing fight against COVID-19."
CTVNews.ca Top Stories
BREAKING Another suspect arrested in Toronto Pearson airport gold heist: police
Another suspect is in custody in connection with the gold heist at Toronto Pearson International Airport last year, police say.
Poilievre-led government 'would never' use notwithstanding clause on abortion, his office says
A Conservative government led by Pierre Poilievre would not legislate on, nor use the notwithstanding clause, on abortion, his office says, as anti-abortion protesters gather on Parliament Hill.
From outer space? Sask. farmers baffled after discovering strange wreckage in field
A family of fifth generation farmers from Ituna, Sask. are trying to find answers after discovering several strange objects lying on their land.
Why these immigrants to Canada say they're thinking about leaving, or have already moved on
For some immigrants, their dreams of permanently settling in Canada have taken an unexpected twist.
Ontario family receives massive hospital bill as part of LTC law, refuses to pay
A southwestern Ontario woman has received an $8,400 bill from a hospital in Windsor, Ont., after she refused to put her mother in a nursing home she hated -- and she says she has no intention of paying it.
Here are the ultraprocessed foods you most need to avoid, according to a 30-year study
Studies have shown that ultraprocessed foods can have a detrimental impact on health. But 30 years of research show they don’t all have the same impact.
Miss Teen USA steps down just days after Miss USA's resignation
Miss Teen USA resigned Wednesday, sending further shock waves through the pageant community just days after Miss USA said she would relinquish her crown.
Cyclist strikes child crossing the street to catch school bus in Montreal
A video circulating on social media of a young girl being hit by a bike has some calling for better safety and more caution when designing bike lanes in the city. The video shows a four-year-old girl crossing Jeanne-Mance Street in Montreal's Plateau neighbourhood to get on a school bus stopped on the opposite side of the street
BREAKING 6 injured in Sharbot Lake, Ont. crash; 2 in life-threatening condition
Ontario Provincial Police say six people have suffered severe injuries in a single-vehicle crash in Sharbot Lake, Ont, including two in life-threatening condition.