Four people were injured - two seriously - and B.C. Highway 99 was closed for several hours after a head-on collision north of Lions Bay Saturday.
The incident took place south of Loggers Creek and north of Brunswick Beach.
B.C. Ambulance Service said four ambulances and a helicopter responded to the scene. One victim was airlifted to hospital, and three others were transported by ambulance.
Squamish RCMP told CTV News two of the four victims were in serious condition.
The crash took place in a part of the highway where there is no divider between north and southbound lanes, police said. One vehicle was traveling north and the other south when they hit each other.
West Vancouver Police and Squamish RCMP responded to the scene. Police said neither alcohol nor excessive speed were believed to be factors in the crash.
By early afternoon, a single lane of the highway had reopened to alternating north and southbound traffic, and by 2:30 p.m. the accident was cleared and all lanes were reopened.